Molecular Formula | C8H17O3* |
Molar Mass | 161.21878 |
Water Solubility | Soluble to 5 mg/ml in water and in 5% acetic acid. |
Appearance | White powder |
Storage Condition | -20°C |
MDL | MFCD00081345 |
In vitro study | MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC 50 of 35.2±7.5 nM. Cell Viability Assay Cell Line: MCF-7 cells Concentration: 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10μM, 100 μM, 1000 μM Incubation Time: Result: Resulted in the production of cAMP with an EC 50 of 35.2±7.5 nM. |
In vivo study | Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min. Animal Model: Swiss male mice (8 weeks old) Dosage: 400 μg peptide /kg body weight (Pharmacokinetic Analysis) Administration: Subcutaneous route; 24 hours Result: Half-time of 23 min. |
WGK Germany | 3 |